Many studies have been performed on Trans Nasal Evaporative Cooling systems. Studies have shown that for the methods used currently it does not occlude the nostrils and no erosion of the nasal mucosa was seen, although care and lubrication was required when inserting the nasal catheters to avoid causing nosebleeds. There was no evidence of sinusitis, tympanic membrane injury or olfactory dysfunction. We would also note that the flow rate of the gas is very low and that it is not always being released. It is only used when the body temperature starts to rise and exceed the target temperature range.
Many reseachers have noted that the procedure may cause an oppressive feeling due to the high volume of circulating air and that it is only suitable in sedated patients. With high flow systems the large amount of dry air was noted to cause stinging and dryness of the nasal mucosa during initiation, but this was temporary and counteracted by either moisturized air or lubricant when placing the tubes.